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實驗型超濾系統(tǒng)LDS-L1Experimental Ultrafiltration System LDS-L1切向流過濾Tangential Flow Filtration，TFF切向流過濾（Tangential Flow Filtration，TFF）是目前應(yīng)用非常廣泛的一種膜分離方法。樣品在壓力驅(qū)動下···

詳細(xì)介紹

實驗型超濾系統(tǒng)LDS-L1

Experimental Ultrafiltration System LDS-L1

切向流過濾

Tangential Flow Filtration，TFF

切向流過濾（Tangential Flow Filtration，TFF）是目前應(yīng)用非常廣泛的一種膜分離方法。樣品在壓力驅(qū)動下，內(nèi)容物根據(jù)分子尺寸不同實現(xiàn)膜過濾分離，達(dá)到去除熱原、置換溶液環(huán)境、純化和濃縮等目的。

Tangential Flow Filtration (TFF) is a widely used membrane separation method. Driven by pressure, the contents of the sample can be separated by membrane filtration according to different molecular sizes, so as to remove pyrogen, replace solution environment, purify and concentrate.

切向流過濾的膜部件通常是膜包或者中空纖維柱，二者均有多種型號，以滿足不同的使用需求。膜材種類和孔徑大小、溶液循環(huán)流速、膜兩側(cè)壓力、樣品溫度、工藝時間等參數(shù)，是切向流過濾非常重要的參數(shù)，它們決定了最終的工藝效果，以及大規(guī)模生產(chǎn)的可行性及具體方案。實驗室規(guī)模的切向流過濾設(shè)備致力于獲得可行的工藝方案和可靠的工藝參數(shù)，為大規(guī)模試驗和生產(chǎn)確定適合的工藝參數(shù)，提供設(shè)備或系統(tǒng)選型的有效依據(jù)。

The membrane components of tangential flow filtration are usually membrane package or hollow fiber column, both of which have a variety of models to meet different use needs. Membrane material type and pore size, solution circulation flow rate, pressure on both sides of the membrane, sample temperature, process time and other parameters are very important parameters for tangential flow filtration. They determine the final process effect, as well as the feasibility and specific scheme of large-scale production. The laboratory scale tangential flow filtration equipment is committed to obtaining feasible process schemes and reliable process parameters, determining appropriate process parameters for large-scale test and production, and providing an effective basis for equipment or system selection.

包裹小分子藥物的脂質(zhì)體和包裹核酸藥物的脂質(zhì)納米顆粒是當(dāng)下非常熱門的兩類藥物載體，他們在研發(fā)和生產(chǎn)中均需使用切向流過濾處理樣品。

Liposomes coated with small molecule drugs and lipid nanoparticles coated with nucleic acid drugs are two very popular drug carriers. They need to use tangential flow filtration to treat samples in R & D and production.

超濾系統(tǒng)圖.jpg

圖1：超濾系統(tǒng)流程圖

Figure 1: flow chart of ultrafiltration system

從濾膜的截留孔徑進(jìn)行分類，可以將過濾分為澄清過濾、微濾、超濾、納濾和反滲透等。將不同孔徑的濾膜采用切向流的操作方式進(jìn)行過濾，即可稱之為切向流微濾和切向流納濾等。

The filtration can be divided into clarification filtration, microfiltration, ultrafiltration, nanofiltration and reverse osmosis. Tangential flow microfiltration and tangential flow nanofiltration can be referred to as tangential flow microfiltration and tangential flow nanofiltration.

濾膜孔徑分類.jpg

圖2：濾膜孔徑分類

Figure 2: filter membrane pore size classification

艾特森LDS系列超濾系統(tǒng)功能

Functions Of AITESEN LDS Series Ultrafiltration System

該系統(tǒng)主要應(yīng)用于樣品的濃縮、提純、透析、置換緩沖液和溶液除熱原等需求領(lǐng)域。過程中可通過無紙記錄儀或液晶面板顯示及記錄樣品的重量、過膜前壓力、回流壓力、透過壓力、跨膜壓TMP等數(shù)據(jù)。

The system is mainly used in the demａnd fields of sample concentration, purification, dialysis, replacement buffer and solution pyrogen removal. In the process, the weight, pre membrane pressure, reflux pressure, permeation pressure, transmembrane pressure TMP and other data of the sample can be displayed and recorded through paperless recorder or liquid crystal panel.

應(yīng)用領(lǐng)域包括：

Applications include:

? 化學(xué)藥品脂質(zhì)體（Liposome）純化，如鹽酸脂質(zhì)體、伊立替康脂質(zhì)體等；

Purification of chemical drug Liposomes, such as doxorubicin hydrochloride liposomes and irinotecan liposomes;

? 核酸藥物和疫苗純化，如脂質(zhì)納米顆粒、聚合物納米顆粒、mRNA-LNP、siRNA-LNP等；

Purification of nucleic acid drugs and vaccines, such as lipid nanoparticles, polymer nanoparticles, mRNA LNP, siRNA LNP, etc;

? 生物細(xì)胞類產(chǎn)品分離和純化，可從發(fā)酵液中收集細(xì)胞并清除細(xì)胞碎片等；

Separation and purification of biological cell products, which can collect cells from fermentation broth and remove cell fragments;

? 疫苗、單抗和重組蛋白藥物的純化；

Purification of vaccines, monoclonal antibodies and recombinant protein drugs;

? 置換緩沖溶液；

Displacement buffer solution;

? 基于分子大小原理分離和純化的其他用途。

Other uses of separation and purification based on molecular size principle.

技術(shù)參數(shù)

Technical Parameter

型號	LDS-L1 & LDS-L2
最小樣品體積	30 mL
壓力范圍	-1 - 5 bar
流速范圍	1 - 2200 mL/min
重量范圍	0 – 4100 g
可顯示數(shù)據(jù)	P_f（進(jìn)料壓力），P_r（回流壓力），P_p（透過壓力），TMP（跨膜壓），△P（壓降）等
操作方式	手動（LDS-L1）自動（LDS-L2）
適用容器	玻璃容器，不銹鋼容器等
適用膜材	PES/纖維素膜包，中空纖維柱
膜包規(guī)格	5 – 1000 kD；0.01 – 0.1 m²

艾特森可根據(jù)用戶需求進(jìn)行定制型設(shè)計和集成，其技術(shù)參數(shù)另行提供。可定制類型包括：

AITESEN can carry out customized design and integration according to user needs, and its technical parameters are provided separately. Customizable types include:

? 不同樣品體積；

Different sample volumes;

? 不同控制方式的要求；

Requirements of different control modes;

? 不同配制檔次的要求；

Requirements of different preparation grades;

? 通用/專用型要求；

General / special requirements;